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Nuby Spouts are made by the parent company Luv 'n Care. Their spouts are manufactured in China under strict US regulations.  The spouts are 100% medical grade silicone so they are naturally bpa free. 

Like all baby nipples and replacement spouts, there are safety issues you should be aware of.  Don't be too upset if the spouts only last a month or two, and be happy if they last that long if your baby is getting teeth and trying to use their Nuby sippy cup spout as a teether. 

WHEN TO BUY NEW SPOUTS:  Watch for signs of wear and definitely signs of tearing.  The spouts will start to become sticky to the touch when you wash them.  If they start to leak all over the place from the tip of the spout, that means that the built in spout valve has been chewed through and the spout needs to be replaced. These are dishwasher safe but for longer use, hand washing works great too.  Use a soft bottle brush and be careful not to break the valves in the spout.